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Why we need female mice in drug trials
Using mainly male mice in drug trials can be problem for women health.
Why do so many promising compounds never become drugs?
Why do possible drugs fail to make it to the chemist?
Postcards from the post-fact front line: Pseudoscience and non-sequiturs as a rationale against research
Patient-derived xenografts in breast cancer research
The National Cancer Research Institute Conference discussed models for breast cancer research.
100,000 birds killed every year from lead shot poisoning
Lead poisoned birds, treatment for arthritis
Suffragettes and other animals
Surprising historical links between the suffragette movement and animal rights activism
Nobel Prize in Chemistry 2015
The 2015 Nobel Prize in Chemistry has been jointly won by Tomas Lindahl, Paul Modrich and Aziz Sancar for “mechanistic studies of DNA repair".
The reason the European Citizens’ Initiative failed is the reason anti-research campaigns are failing generally
Pro-Test Italia demonstrate the value of animal research
On Saturday 1st June 2013, Pro-Test Italia held a rally in support of the important role that animals play in biomedical research.
Pro-Test Italia march on Saturday
The Pro-Test Italia rally will culminate in the delivery of a petition signed by over 5000 people calling for solidarity with the researchers affected by the attack.
How to distort 0.004% of the statistics
A new statistic is doing the rounds in the animal rights camps.
Dementia Awareness Week: 19 – 25 May
This year’s Dementia Awareness Week is themed around talking, with the message that “Worrying changes nothing.
Animal research news round up 10/05
The Daily Mail, in an earnest attempt to justify their drinking habits, reported that phenolic acid found in champagne dramatically improved the memory test performance of rats.
Brain Injury Week 13th - 19th May 2013
This year's Action for Brain Injury Week (ABI Week) will see the launch of a positive campaign aimed at GPs to assist them with diagnosing and appropriately signposting patients and carers affected by the often hidden aspects of brain injury.
New animal research briefing for Deaf Awareness Week
UAR has produced a new briefing sheet on deafness and hearing loss as a contribution to Deaf Awareness Week (6th May - 12th May 2013).
Prize for technique that reduces number of animals in spinal injury research
A scientist from the University of Glasgow has been awarded a 3Rs Prize for developing a cell-based technique that models severed nerves usually studied in animals.
Newly identified naturally occurring hormone could treat diabetes
Experiments in mice have identified a hormone that could stop and even reverse the onset of diabetes.
Animal research news round up 03/05
The possibility of eternal youth is guaranteed to get coverage and all the broadsheets covered this Nature story this week.
Pint of Science
World-leading scientists will be sharing their knowledge and latest discoveries in pubs across London, Oxford and Cambridge from Tuesday 14th - Thursday 16th May.
Novo Nordisk wins Corporate Responsibility award
The annual Corporate Responsibility Reporting Awards were handed out at the Royal Society earlier this week.
Scientists ask for solidarity
A recent break in at the University of Milan by animal rights extremists has put the university’s research into psychiatric disorders back several years.
World Malaria Day
This World Malaria Day, April 25th, we need to remember the global significance of this life-threatening disease.
Animal research news round up 26/04
Hilary Koprowski, the scientist who developed the first live-virus polio vaccine, has died at the age of 96.
Two thirds of the British public are unaware animal cosmetic testing is illegal in UK
Almost two thirds of British people (63%) do not know that is it illegal to test finished cosmetic products on animals in the UK, according to a recent ComRes survey.
Animal research is leading a revolution in organ transplants, again
Around the turn of the 20th Century, two surgeons named Emerich Ullman and Alexis Carrel placed the kidney of goat into a dog.
Animal rights extremists wreck Milan laboratory
An animal facility at the University of Milan, Italy, was occupied on Saturday 20 April by Fermare Green Hill.
Animal research news round up
We have several stories which very clearly illustrate the potential medical benefits of research this week.
News round up
Robert Edwards, the Nobel Prize winning developer of in vitro fertilisation, has died at the age of 87.
We have a lot of things to thank animals for; space travel and cloning are just two of them
Dolly is probably the most famous animal ever to take part in a scientific experiment.
Researchers studying mice have discovered that brain cells may break their own DNA to form new memories.
New malaria medicine developed in mice
An experimental compound has proved highly effective at preventing malaria in laboratory tests using mice.
UAR at The Big Bang Fair 2013
The UAR Education Team had a fantastic time at The Big Bang Fair at ExCel in London which ran from the 14th -17th March this year.
New foot-and-mouth vaccine
Foot-and-mouth disease (Aphthae epizooticae) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovids such as cattle and sheep.
Gene therapy targets 'cancer gene'
Gene therapy using a mutant form of a gene known to be involved in many of the most common cancers can destroy tumours in mice without any major side effects.
Mice experiments help scientists improve cancer vaccines
An additive used in anti-cancer vaccines is stopping them working properly, research in mice suggests.
Achilles’ heel identified for rare cancer
Research using genetically modified mice has given scientists a unique insight into the molecular cause of an incurable human cancer.
UAR sets up a new website: AnimalRightsExtremism.info
Animal rights activists have created an exaggerated impression of their movement by their use of social and other media channels.
Pain makes the heart grow stronger
Scientists working with both mice and people have found that painkillers could actually hinder the body’s recovery after a heart attack.
Nearly £1 million towards replacing cancer tests
Scientists have been awarded nearly £1 million to develop new test methods that should substantially reduce the numbers of animals used for testing chemicals which may cause cancer.
Gene therapy treats blindness in dogs
A common form of blindness has been successfully treated in dogs using gene therapy.
Nanoparticles boost vaccines
Scientists have developed nanoparticles that boost the effectiveness of vaccines in mice by mimicking part of the natural immune response.
Beagle breeding planning appeal fails
On Thursday 26 January, we learned that Communities Secretary Eric Pickles had agreed with the recommendations of a planning appeal inspector and dismissed the planning appeal by B&K animal breeders in East Yorkshire.
Rats jump aboard
On the principal that you can’t really understand something until you have tried it yourself, the UAR education team has been encouraging young people up and down the country...
Stem cells and heart repair
Continuing our video series on the patient benefits of animal research, a patient interviews a scientist on how stem cells, based on animal research, may be used to repair hearts.
Schizophrenia and sleeping problems linked?
Recent findings that a gene associated with schizophrenia also causes abnormal sleep patterns in mice have led scientists to ponder whether the mental illness and sleep disturbance could be genetically linked.
Worm holes and lung damage
New research suggests that understanding provided by parasitic worms could be used to treat serious lung injury caused by infections.
Omega-3 fatty acids protect against nerve damage
Scientists have found that omega-3 fatty acids can help speed up recovery from nerve damage.
One dog, 90 years, millions saved
Before January 1922, a diagnosis of Type 1 diabetes was in effect a death sentence; many died of starvation.
Cell walls can bock infections
Scientists have developed a new strategy for fighting infectious diseases.
Rare eye cancer pathway uncovered
Scientists have uncovered the secret behind the rapid progression of retinoblastoma, a rare type of childhood eye cancer.
Young blood treats old mice with MS
By transplanting cells from the blood of young mice, scientists have successfully stimulated stem cells to repair the damaged nerve tissue of old mice with multiple sclerosis.
HIV vaccine boost
Scientists have created a vaccine that protects rhesus monkeys from infection by the simian immunodeficiency virus (SIV), a relative of HIV, the virus that causes AIDS.
Gene could hold key to treating deafness
Scientists have identified a gene that, when deleted, causes deafness in mice.
Intricate experiments using mice have allowed scientists to visualise the formation of new brain circuits that form after birth.
Cancer treatment targets tumour growth protein
A chemical tested in mice, cell cultures and human biopsies has proved highly effective in preventing the growth of tumours.
Gene confers resistance to Marek’s disease
Scientists have identified a gene that appears to make chickens immune to the deadly Marek's virus - responsible for millions of deaths in chickens each year.
Tuning the immune system reverses MS
Scientists have found a way to reverse the devastating effects of multiple sclerosis (MS) in mice.
Vaccine protects mice against deadly Ebola virus
Scientists have developed a vaccine which protects mice from the Ebola virus and, unlike current vaccines, can be stored for long periods of time.
Weight loss treatment works in obese monkeys
Researchers have shown that a new compound can significantly reduce the weight of monkeys by destroying blood vessels that feed fatty tissue.
The Parliamentary Under Secretary of State for the Home Department, Lynne Featherstone, advanced an animal research policy based on evidence in a Commons debate on Wednesday 7 December.
World AIDS Day
It's 30 years since the first cases of HIV infection. During this time, says the website HIVaware, we've seen rapid change.
#WW award for Overlooking the Importance of Animal Research
We liked a piece in the Huffington Post by Kirk Leech. Overlooking the Importance of Animal Research in the UK politics section of the Huffington Post...
GM cells cure anaemia in mice
Mice have been cured of anaemia by an injection of genetically engineered cells that, when injected underneath the skin, formed blood vessels that secreted a hormone called erythropoietin.
Information tribunal rules for both sides
As anyone who reads it will see, a recent (11 November) Freedom of Information ruling falls some way short of the 'landmark decision' claimed by BUAV.
Naked mole rat DNA exposes its age-defying secrets
A team of scientists have begun to unravel the secrets underlying the long life enjoyed by naked mole rats.
Blood protein from rice treats rats
A human blood protein has been produced using genetically modified rice and used to treat liver disease in rats.
Release of leading extremists may inspire new attacks on animal research
Leading animal rights extremists Greg and Natasha Avery were released from prison this week.
Why don't woodpeckers get headaches?
How do woodpeckers avoid injury to their brain as their beak hits a tree at seven metres per second and up to 100 times per minute?
Blocking brain cancer in mice
An interaction between two proteins has been found to be essential for the development of the most common form of brain cancer.
#WW award for Of Mice and Medicine
We award Paul Vallely of the Independent newspaper for his excellent article - Of Mice and Medicine.
Modified protein treats haemophilia in mice
Scientists have engineered a human clotting factor into a safe and effective treatment that cured haemophilia in mice.
Chemotherapy delivered through the nipple
Tests in both rats and patients have shown that chemotherapy delivered through the milk ducts of the nipple is more effective and leads to fewer side-effects than intravenous drug delivery.
Lords again affirm support for animal research
Several peers confirmed their belief in the need for animal research in biomedical research, during a debate in the House of Lords yesterday (24 October 2011).
Of mice and medicine
Subtitled In defence of animal experiments, the Independent published a four-page article in Saturday's Magazine about how animal research is 'transforming human lives'.
New antibody protects monkeys from deadly Hendra virus
Squamous cell skin carcinoma is the second most common skin cancer after melanomas, affecting approximately 10,000 people in the UK each year.
Enzyme linked to miscarriages and infertility
Studies of patient tissue and experiments using mice have linked a specific enzyme to both infertility and miscarriage.
Sickle-cell anaemia treated in mice
Researchers have shown that they can treat sickle-cell anaemia in mice by switching on a haemoglobin gene usually only active before birth.
#WW award for Zebrafish article in Wellcome News
The article by Emma James in the latest Wellcome News looks into why zebra fish have become so important in genetics research.
Diabetes 'cured' with brain stem cells
Stem cells taken from a rat's brain using a simple procedure have been made to produce insulin and used to cure diabetes in the same rat.
Of mice and men - new video
Watch the 'Of Mice and Men' videos to see how GM mice are used to study human disease.
Less is more for common cancer treatment
A common cancer treatment has been shown to be more effective and less toxic when administered at more frequent, lower doses.
Lords affirm support for animal research
Members of the House of Lords on Tuesday affirmed their support for 'proper and appropriate' use of animals in medical research.
#WW award for NC3Rs review
Our Wedneday Winner today is the NC3Rs for producing a really clear, accessible and comprehensive review of the work it funds.
Cancer inducing protein protects against diabetes
Scientists have uncovered an intriguing signalling pathway linking cancer and diabetes.
The research they tried to stop
Three animal rights extremists who were imprisoned for their role in the 'Save the Newchurch Guinea Pigs' campaign – Jon Ablewhite, John Smith and Kerry Whitburn – have been released from prison.
Anti-viral medicine slows brain tumour growth
Scientists have found that the growth of Medulloblastoma brain tumour cells in mice can be significantly slowed using existing anti-viral medicines.
Mouse stem cells guided to become neuron-protecting cells
Scientists have successfully guided mouse stem cells to become specialised cells that build a protective coat around neurons.
How the brain communicates with the immune system
Experiments on mice have identified the missing link that allows the nervous and immune systems to communicate.
Neuron’s self-defence against dementia
Scientists have identified a signalling pathway used by neurons to protect against the cause of frontotemporal dementia, the second most common form of early-onset dementia after Alzheimer's disease.
Treating 'Alzheimer's disease' in mice
Scientists working with mice have identified a molecule that appears to cause the dementia suffered by Alzheimer's patients.
UK Bioscience Coalition position on the European Directive on animal research
Animal research is vitally important in science and medicine.
Replacing animals with nerves on a chip
A team of scientists have developed a way of guiding nerve cells to set up complicated networks that mimic the ones found in the brain.
#WW award for a letter from Parkinson's UK
Animal Aid is running a campaign against medical charities because some of their funded work involves animals.
'Glow in the dark' cats aids HIV research
Scientists inserted two genes into cats: the first is taken from macaque monkeys and helps the cat resist the feline form of Aids; the second is a fluorescent gene from jellyfish that helps the researchers literally see where the added anti-aids gene is active.
Colchicine from Crocus kills cancer
A modified version of a chemical found in the Autumn crocus has shown exceptional promise as a tumour-killing agent in mice and will soon begin clinical trials in humans.
Gene deletion blocks pain
Scientists have identified the gene that allows the transmission of chronic pain.
Safer treatment for sleeping sickness
Scientists have trialled a safer way of treating sleeping sickness in mice by modifying an existing medicine.
Modified bacterium protects against TB
Mice infected with a genetically modified relative of the tuberculosis bacterium became immune to tuberculosis, a new study has shown.
Computer model predicts effect of medicines on heart
Scientists have developed a computer model that predicts the effect of anti-arrhythmic medicines on the heart.
Stem cell treatment for stroke trial
A treatment developed in rats and mice has been shown to be safe in the first ever human trial of stem cell treatment for stroke victims.
Gene therapy hope for Menkes Disease
Studies in GM mice have shown that a combination of gene therapy and copper injections could be effective in treating Menkes Disease, a lethal and progressive disease that mainly affects young boys.
Gene mapping opens new insights into the brain
A map of gene activity has been created that scientists hope will shed new light on the causes of Alzheimer’s and Parkinson’s diseases.
Breakthrough against deadly Ebola virus
Scientists have uncovered the Achilles heel of the deadly Ebola virus; the breakthrough could lead to the first treatment for the tropical disease within a decade.
Obese mice fed artifical enzyme live longer
A new artificial enzyme(SRT1720) has been found to increase the lifespan of obese mice.
Gene therapy treats Duchenne muscular dystrophy
Modified stem cells have been used to treat Duchenne muscular dystrophy (DMD) in mice by replacing the faulty gene that causes the disease with a normal version of the gene.
Ear cells could be used in facial reconstruction
Tissue grown from stem cells taken from patients' ears could be used in facial reconstructions, tests in mice have shown.
Why fatty diet can lead to type 2 diabetes
Rates of diabetes have doubled in the last 30 years and doctors say rising levels of obesity are the main contributing factor.
#ww Buffering brains against stress
The hippocampus creates new neurones throughout our lives - so what happens if you bring "the hippocampus's production line to a screeching halt?"
Artificial protein could be 'universal' anti-viral
Antibiotics such as penicillin can be used to treat all sorts of bacterial infections, but doctors have few options when it comes to viral infections.
Some facts about Parkinson's and Alzheimer's research
The animal rights group Animal Aid launched an ill-informed, illogical and ill-conceived campaign against medical research charities a few weeks ago.
Mouse births from stem cell sperm
In the UK around 1 in 10 men are infertile, often because of low sperm counts.
Allergy testing with human cells
Allergic reactions to everyday chemicals are common causing eczema in millions of people, and tests on animals have been important in testing new chemicals for skin sensitisation.
Starving kidney cancer in mice
Researchers have identified a new chemical (STF-31) that selectively kills kidney cancer cells by blocking their glucose supply.
Cancer treatment for 'schizophrenic' mice
Schizophrenia is one of the most common serious mental health conditions in the UK, affecting 1 in 2000 people at some time in their lives.
Shining a light on ataxia
When people stagger after drinking too much ethanol has caused reversible ataxia – a loss of muscular co-ordination.
#ww Can scientists follow Laura’s lead?
Mark Henderson’s Science Matters column in today's Times Eureka gets our #ww Wednesday Winner award for communication about animal research (OK, it’s not Wednesday, but this column is a deserving winner).
Broken sleep disrupts memory
Research on mice has shown that uninterrupted sleep is vital for memory consolidation.
Coalition pledge on household product testing
This month’s awaited pledge by the coalition government to end household product testing on animals has been welcomed by the UK research community.
#ww award for the Ark Hive
Dr. Paul Foster, a Lecturer in Molecular Endocrinology at the University of Birmingham, is an experienced cancer researcher and pharmacologist with a strong interest in understanding how animals help advance medical research.
UK research using monkeys 'outstanding'
A report published today, called Review of research using non-human primates, recommends that scientific research on monkeys should continue in the UK, subject to rigorous safeguards.
I'm a scientist: get me in there!
For two weeks this June I took part in the 'I'm a scientist...get me out of here 2011' competition at the Wellcome Trust.
Animals containing human material
What are 'animals containing human material' (ACHM) and why the sudden interest in them?
Helping the hunt for disease genes
A few weeks ago it was announced that researchers have created genome-wide, high-resolution genetic maps of 100 inbred mouse strains.
Mice with human livers
To better study the breakdown and toxicity of new medicines in a human liver, scientists have created what has been named a ‘humanised mouse'.
Meningitis B vaccine one step closer
A study using mice has led scientists one step closer to developing a vaccine against the most common cause of bacterial meningitis, Meningococcus B.
Committing to the three Rs
The UK Home Office this morning agreed arrangements to deliver two Coalition commitments relating to the use of animals in scientific research
Spine repair allows rats to breathe again
Injuries that damage the spinal cord at the top of the neck can damage the nerve connections between the respiratory centre in the brain and the diaphragm muscles that we need to breathe normally.
#ww Animal models: Inside the minds of mice and men
Monya Baker has given us a good and useful read. Her article in Nature provides many examples of animal models for human conditions and gives a clear appraisal of their value.
Brain tumour growth slowed
Brain cancers caused by malignant gliomas account for around 3,000 deaths in the UK each year.
Polar bears and brown bears interbred
A genetic study of living and the ancient remains of polar and brown bears has revealed that they interbred during the last ice age and that modern polar bears are descended on the female side from brown bears that lived in Ireland.
Reversing Rett Syndrome in mice
New research using mouse models has shown that glial cells, which protect and support neurons in the brain, play a central role in preventing the severe symptoms of Rett Syndrome.
But can they suffer?
'The question is not can they reason nor can they talk, but rather can they suffer?' Jeremy Bentham
Millions owe their lives to animal research
Leading research organisations have responded to misleading claims made by an antivivisection group in its recent letter to the Lancet.
Cheap treatment for sleeping sickness
Researchers are preparing for clinical trials of the first inexpensive oral treatment for Trypanosomiasis, the parasitic disease commonly known as sleeping sickness that is transmitted to humans by the tsetse fly.
Gene repair treats haemophilia
About one in 30,000 boys are born with a defective gene that causes haemophilia B.
SchoolZone Goes Live
The UAR SchoolZone is a brand new part of our site dedicated to school age students and their teachers.
Animal research and diabetes
In this film we hear from Chloe, who has diabetes, and Dr Aileen King, who researches into diabetes.
#WW award for ... Animal research is helping us beat cancer
'Thanks to decades of research, survival from cancer has doubled in the last 40 years, giving thousands of people more time with their loved ones.
Vaccine shrinks prostate tumours in mice
A vaccine containing a broad spectrum of tumour antigens delivered in a virus vector successfully treated 8 out of 10 mice with prostate cancer.
Why do charities fund animal research?
The animal rights group Animal Aid has launched a campaign against medical research charities who fund animal research.
Chemical in apple peel strengthens muscle
An apple a day really does keep the doctor away according to a new study in mice.
New regulations will boost good science, promote animal welfare
New animal research regulations from Europe will enhance the welfare of animals, facilitate modern science and cut through excessive red tape.
CJD research potential for Alzheimer’s
Researchers working on treatments for the brain disorder Creutzfeldt-Jakob Disease (CJD) may have found a potential treatment for Alzheimer’s disease.
Heart repair initiated in mice
Human hearts cannot repair themselves after a heart attack damages heart muscle.
New mouse model for hepatitis C
The hepatitis C virus infects in the region of 170 million people around the world and creates an increased risk of cirrhosis, liver failure and cancer.
UAR in Mauritius
Macaques, like humans, are not indigenous to the island of Mauritius, isolated as it is in the Indian ocean.
Protein suppression stops leukaemia growth in mice
Leukaemia causing stem cells have been eliminated in mice by suppressing two proteins.
‘Trojan Horse’ brain cancer treatment increases lifespan
A novel ‘Trojan horse' method of treating brain cancer has increased the survival time of mice by one half.
BBC interviews UAR about beagle breeding plans
Animal rights protestors are targeting the beagle breeding company B&K Universal's plans for modernisation of their site in Grimston.
Targeting genes to stop breast tumours
Some breast cancers do not respond to currently available chemotherapy.
This months Wednesday Winner website (#WW) is Rodent Respect. The site was created for scientists who work with rodents, especially students.
Do-it-yourself animal research
It is often said that the only way to really learn anything is to do it yourself.
Armadillos infect humans with leprosy
Armadillos can infect humans with leprosy, according to a new study comparing the disease in US patients and armadillos.
Skin cancer protein identified in mice
Scientists have identified a protein that suppresses skin cancer in mice.
A history of Beecham’s
The story of Thomas Beecham, founder of the company that went on to become part of Glaxo SmithKline, is quite extraordinary.
Mouse model of human immune system validated
A mouse model of the human immune system has been validated by replicating the results of a recent human HIV clinical trial.
Prostate tumours reduced in mice
Prostate tumours have been in reduced in mice using a medicine originally designed to treat obesity.
Nine cell types to re-grow a fin
Understanding regeneration in model organisms gives hope that it may one day be possible for amputees to regrow limbs, or for heart attack patients to regrow healthy heart muscle.
Vulture decline slows
The ban on a veterinary medicine which caused an unprecedented decline in Asian vulture populations has shown the first signs of progress.
#WW - Untangling the brain
Our brains are a dense tangle of billions of nerve cells connected together at synapses. Knowing how everything links up is key to understanding how the brain works – but it's a huge challenge.
Vaccine protects monkeys against SIV
A vaccine has been developed that protects monkeys from Simian Immunodeficiency Virus (SIV), the monkey equivalent of HIV.
Creation of new Animal Welfare Centre in Scotland
The Scottish Agricultural College (SAC) is to coordinate a major, new, EU funded, research project to create a Centre of Excellence in Animal Welfare Science.
Number of nerve stem cells declines with age
A new study may explain why our brains produce fewer new neurons with age.
Antidepressants stimulate nerve cell growth
Stress can cause depressive illness in humans and has visible effects on mice such as failure to groom and weight loss.
Possible treatment for muscular dystrophy
About 100 boys are born with muscular dystrophies every year in the UK.
Technique mass produces neural stem cells
Stem cells hold the promise of cures for injuries such as spinal cord damage and diseases such as Parkinson's but producing large quantities of cells for experiments and clinical trials is proving very difficult.
How exercise protects the heart
Work with mice has shown that the elevated levels of nitric oxide produced during exercise protect the heart from injury during a heart attack.
European Chemical Agency call for animal test data
Chemical safety in Europe is regulated in part by REACH*.
#WW Wednesday Web award - Smallpox Through Time
In Elizabethan times smallpox killed more people than TB, leprosy, plague and syphilis combined.
How TB destroys lungs
GM mice have helped identify a key enzyme responsible for destroying lung tissue in tuberculosis (TB).
UAR appoints Interim CEO
The UAR Council is delighted to announce that, following a rigorous selection process, we have recruited David Pruce as Interim Chief Executive to ensure that our important work continues and thrives.
Aspirin may reduce effects of Prozac
Aspirin and other anti-inflammatory medicines taken for pain relief may reduce the effectiveness of antidepressants such as Prozac.
New hope for MS
Unlocking a key messenger protein in the body’s defences could be a first step to new treatments for multiple sclerosis (MS) and other autoimmune diseases, suggest studies in mice with a form of the disease.
Are wild animals happier?
Are wild animals happier? That was the question posed by Christie Wilcox for a guest blog in Scientific American.
Gene linked to lung cancer spread
Scientists have identified a genetic change that makes lung tumours more likely to spread to other parts of the body.
Growing new blood vessels in mice
Heart attacks and strokes could be prevented using a new method of blood vessel regeneration, according to research on mice.
Virtual rats' whiskers
A new computer model of rats' whiskers is helping scientists understand how rats process the sense of touch.
Genes temporarily turned-off
Scientists have created a new method to temporarily turn off the function of genes in mice.
Memory loss linked to stress
Scientists have discovered how stress contributes to memory loss in old rats.
UK public opinion largely positive
Recent research on public attitudes to animal experimentation has been published on the Ipsos MORI website.
A Question of Care
From our archive - this video about the care of laboratory animals was produced by the Biomedical Research Trust in 2003.
New mechanism links type-2 diabetes to obesity
Scientists have discovered a mechanism linking type-2 diabetes to obesity.
Stem cells for skin repair
New treatments for chronic wounds could be developed following the discovery of stem cells that repair damaged skin tissue.
Fish for Science is the first Wednesday Winner
We've awarded our first Wednesday award to The MRC Centre for Developmental and Biomedical Genetics for their Fish for Science website.
Genes for acute myeloid leukaemia
Scientists have identified three types of gene mutation that lead to acute myeloid leukaemia.
New skin cancer gene, new treatment
The discovery of a gene linked to skin cancer in zebrafish could lead to new treatments for the disease.
Be a Wednesday Winner #WW
We are starting our very own webby awards, which we are calling Wednesday Winners (#WW).
The teenager who took a stand against animal rights protesters
Laurie Pycroft, who founded Pro-Test five years ago, was profiled in The Independent Education section today.
European chemicals industry to develop non-animal toxicity tests
The European Chemical Industry Council (Cefic) has launched a £450,000 research project into finding non-animal methods of toxicity testing.
Multiple sclerosis reversed in mice
The process of nerve cell degeneration in multiple sclerosis (MS) can be reversed, according to new research in mice.
Protein linked to autism in mice
Research on GM mice has found how mutations in a single protein can lead to autism.
Jamie’s Dream School – animal madness?
In his science lessons for Jamie’s Dream School on Channel 4, Lord Winston showed the dramatic (in more ways than one!) impact that using animals can have in science lessons.
Optimising GM mouse research
'The MRC is absolutely committed to basic research and we understand the value of mouse genetics', said Professor Sir John Savill, CEO of the Medical Research Council today, announcing a multi-million pound investment in mouse genetics.
GM pig gets cystic fibrosis
A GM pig that gets cystic fibrosis is helping scientists understand the causes of the disease.
Mice sperm grown in the lab
Treatments for infertility in men could come from success in growing mouse sperm.
UAR makes a Big Bang
UAR teamed up with the Y Touring Company this month for a series of workshops about the use of animals in research at this year's Big Bang Science Fair held at London's Excel Centre.
RatCAP brain scanner
Scientists have developed a mini brain-scanner that allows them to study brain function and behaviour simultaneously in rats.
Did you know that it is exactly 100 years since a little-known researcher called Francis Peyton Rous in New York discovered that chickens could get cancer from viruses? We didn’t think so.
Mouse mimics another childhood brain cancer
Scientists have created a mouse model of the most common type of paediatric brain cancer.
Poor diet in pregnancy linked to diabetes in offspring
Poor diet during pregnancy could raise the risk of offspring developing diabetes, according to new research in rats.
New research suggests macaques experience self-doubt and uncertainty when making decisions.
Tiny sensors monitor heart attacks
The severity of a heart attack can be determined using tiny implanted sensors, according to new research on mice. Similar sensors could be used to monitor people at high risk of heart attack.
Black-footed kittens born through IVF
IVF has helped millions of couples achieve pregnancy, and not only in humans: it was with IVF that scientists recently produced these amazingly cute kittens.
Heart regeneration in newborn mice
Newborn mice can regenerate their own heart tissue following heart damage.
Mouse mimics childhood brain cancer
Scientists have created the first mouse model of a deadly form of childhood brain cancer.
Exercise reduces ageing in GM mice
Regular endurance exercise reduces the effects of ageing, according to new research on mice.
Artificial blood vessel success in animals
Artificial blood vessels for use in heart bypass surgery have been successfully tested in baboons and dogs.
New understanding of 'suspended animation'
Research on bears has extended our understanding of large mammal hibernation.
Enzyme reduces cancer spread
The spread of cancer to other organs has been reduced in mice by blocking an enzyme.
European medical science group states position on new law
The medical science group within the European Science Forum (ESF-EMRC) has produced a position paper on the new Directive on the Protection of Animals used for Scientific Procedures.
Spinal cord damage bridged in rats
Artificial ‘scaffolding' has been used to bridge spinal cord injuries in rats.
Wounds trigger tumours
Certain types of cancer could be triggered by simple wounds, according to new research on mice.
Kidney regenerator cell identified
Zebrafish are renowned in the science community for their ability to repair damage to heart muscle.
Watch and read - Where do medicines come from?
We've produced a new leaflet and accompanying video that is being distributed to GP waiting rooms throughout the UK for the next six months.
Enzyme linked to blindness
Age-related macular degeneration (AMD) has been linked to the lack of a protective enzyme in the retina.
HIV-like virus cured in mice
Scientists have used a hormone to completely remove a HIV like virus from mice.
Protein predicts cancer spread
Scientists have identified a protein that tumours make when they are likely to spread.
Cancer medicine could treat spinal injury
The cancer medicine Taxol has been used to treat spinal injury in rats.
Gut bacteria affect brain development
Bacteria in the gut acquired early in life could affect future brain development and behaviour, according to new research on mice.
Hormone improves memory in rats
A hormone has been found that boosts the memory of an unpleasant experience in rats.
Lack of omega-3 linked to mood disorders
Mice fed a diet lacking in the fatty acid omega-3 are more susceptible to mood disorders, according to new research.
Tiny camera reveals brain changes in real time
An innovative new instrument has been developed that enables scientists to observe changes deep inside the brains of animals.
Caffeine could cure hangover headaches
Caffeine and painkillers could be the most effective cure for a hangover headache, suggests new research on rats.
Fighting cancer with cancer
An innovative new approach to fighting cancer has reduced tumour size in mice.
New video - mice as a model for Alzheimer's disease
Mice can be used to mimic Alzheimer's disease in humans.
RNA based medicine for HIV
A potential RNA based treatment for HIV is showing positive results in tests on mice.
UK scientist wins prize for improving animal welfare
Each year the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) awards a prize for innovative research which has an impact on the use of animals in life sciences.
UAR CEO moves to SGM
Dr Simon Festing, the Chief Executive of Understanding Animal Research for a little over six years, is leaving the organisation to take up the post of CEO of the Society for General Microbiology (SGM).
Scientists closer to MRSA vaccine
Scientists are closer to developing a vaccine against the superbug MRSA.
MicroRNA combats prostate cancer
Small strands of RNA, called microRNA, inhibit prostate cancer stem cells in mice.
Zebrafish grow abnormally in microgravity
Zebrafish raised in microgravity, replicating the conditions of space, develop skull defects.
GM chickens prevent transmission of bird flu
Bird flu epidemics could be prevented by GM chickens that stop the spread of flu to other birds.
Artificial intestine reduces animal tests
An artificial human digestive system is replacing the use of animals in some tests to see how medicines are absorbed, The Times reported last week.
Stem cells could end blood platelet shortage
Blood platelets produced from embryonic stem cells have been used to repair damaged tissues in mice.
Vaccine induces cocaine immunity in mice
Cocaine immunity has been induced in mice using an altered version of the common cold virus.
Genetic modification strengthens hearts
Mice have been genetically modified to grow stronger hearts.
Horse genital cancer virus identified
Scientists have discovered a virus linked to genital cancer in horses.
Mechanism behind autism uncovered
Nerve cells that are unable to communicate effectively may be responsible for autism spectrum disorders (ASDs), according to new research on mice.
Rats sniff out tuberculosis
Gambian pouched rats are being used by scientists to sniff out tuberculosis in mucus samples.
Zebrafish improve understanding of cancer growth
Experiments on zebrafish larvae have revealed how cancer cells harness the immune system to quicken the spread of the disease.
Art meets science in mouse's brain
Animals have been used to understand the inner workings of the brain since the very beginnings of neuroscience.
How you live now impacts on the children you have yet to conceive
Smoking or drinking while pregnant can damage the unborn child.
World-leading research institute gets go-ahead
We are pleased to report that planning permission was granted last week for a new world-leading biomedical research institute in London.
Alzheimer’s reversed in mice by memory protein
Memory loss has been reversed in Alzheimer's mice by boosting levels of a memory related protein.
Childhood flu may protect against asthma
Exposure to bacteria or viruses as child could reduce your chances of contracting asthma, according to new research on mice.
Stem cells combat muscular dystrophy
A new mouse model of muscular dystrophy has found that stem cells play an important role in this genetic disease.
Freedom of Information - judgement on confidentiality clause at a university
Recently, a tribunal ruled that under the Freedom of Information Act a university can be said to 'hold' project licences (irrespective of how they are actually stored at the university) and that section 24 of the Animals (Scientific Procedures) Act 1986 (ASPA) would not prevent disclosure of information from the project licences.
Biological clock pigment could help blind people
Light sensing cells (photosensitive ganglion cells) in the eye, which contain the pigment melanopsin, set the body's biological clock.
Following directly from the Basel Declaration that we covered on Tuesday, an editorial in Nature, 9 December 2010, has urged German science to set up an organisation like Understanding Animal Research to engage the public on the medical benefits of animal research.
Dementia confuses memories
Confused memories rather than memory loss may be the cause of 'forgetfulness' in dementia patients, according to new research.
Winter birth may alter biological clock
Being born in winter could make your long-term biological clock tick slower, according to a new study on mice.
Enzyme causes chronic pain
An enzyme responsible for making pain last after nerve injury has been discovered in mice.
Basel Declaration calls for open dialogue
More than 50 top scientists working in Germany and Switzerland have launched a new Declaration about animal research.
Focus on fluorescent filming
The Scientist reported on its top ten life-science innovations for 2010 this week.
Scientists create 'couch potato' mouse
By removing a protein that muscles use to convert fuel into energy, the researchers produced a mouse with normal body weight but which did not have enough energy to exercise.
How much effort on alternatives? The answer is a lot
Our attention was drawn this week to a relatively new European initiative called AXLR8, a consortium which aims to accelerate progress in developing alternatives to animals for safety testing.
Ageing reversed in mice
Premature ageing can be reversed in mice, hinting at the possibility of anti-aging treatments for humans.
World AIDS Day - 1 December
The HIV & AIDS page on our partner website AnimalResearch.info has been updated to mark World AIDS Day on 1 December.
Infiltration: most allegations unfounded
Understanding Animal Research today (Tuesday 30 November) welcomed a report from the Home Office addressing claims by an animal rights group about animal research and testing at a UK facility in 2009.
New European law marks dawn of a new era
The new European Directive 2010/63/EU on animal experimentation has been finalised.
New video: Why do we use animals in research?
In this short interview with Dr Simon Festing, we hear his response to questions such as: Why is their so much secrecy in animal research?
Changing nerve cells could treat spinal injury
Nerve cells made from a person's own skin suggest a novel way to treat spinal injury.
Compound controls weight and blood sugar
A new compound has been designed that controls weight and blood sugar in mice, raising the prospect of a treatment for sufferers of obesity and diabetes.
Shining a light on depressive disorders
Depression and anxiety affect a significant proportion of the British population, yet the underlying causes behind these medical disorders remain elusive.
How familiarisation breeds contempt
How do we learn to recognise new sensations and distinguish them from those we are already familiar with?
Blood pressure medicine could treat Alzheimer’s
A medicine previously used to treat high blood pressure could now be applied to Alzheimer's disease following tests on GM mice.
Pregnant mice point to treatment for premature labour
Scientists have found that the onset of labour is controlled by tiny molecules called microRNA.
World Diabetes Day - 14 November
World Diabetes Day (WDD) is the primary global awareness campaign of the diabetes world.
GM mouse immune to cancer
Cancer tumours somehow escape the body's immune system, even when that immune system is primed by a vaccine designed to specifically target the cancer.
Gene mutation increases dementia
The dementia associated with Alzheimer's and Parkinson's diseases is commonly associated with abnormal clumps of a protein (B-synuclein) in the brain.
Mice treated for memory loss
Mice treated with a brain enzyme inhibitor performed better in memory tests than untreated mice.
New government committed to continued crackdown
Following the sentencing of six animal rights extremists on Monday, the new government made clear that it remains committed to countering criminal activity carried out in the name of animal rights.
New video - How much animal research in the UK?
A new video, How much animal research is done in the UK, is now available in our youtube site and in the video section in the resources page on this website.
Deadly rinderpest virus eradicated
The UN has just announced that rinderpest, a virus that used to cause deadly outbreaks in cattle, has been eradicated in the wild.
Congenitally deaf cats have better peripheral vision
When the brain is deprived of input from one sense it often compensates with above normal performance in another sense.
Elixir of life?
Supplementing the diet of healthy middle-aged mice with a mixture of amino-acids - the building blocks of proteins - extended their average lifespan by over one tenth.
Potential treatment for terminal cancer
For the first time, researchers have discovered a therapy that can treat the invariably lethal terminal stages of cancer in animals.
The top 100 scientists in Britain today
The first list of its kind for science, The Eureka 100: The Science List by The Times last week aimed to identify the 100 most important people in British science.
Mice muscles controlled by light
How do you re-animate paralysed limbs? A new approach being trialled on genetically modified mice uses flashes of light.
No retirement for chimp colony
186 chimps currently housed in unofficial retirement in the Alamogordo Primate Facility in New Mexico are to be re-housed in the Southwest National Primate Research Center.
Mice and monkeys metabolise BPA like humans
New research shows female mice, monkeys and humans appear to metabolise the oestrogen-like chemical bisphenol A (BPA) in similar ways.
Free course on science communication
The National Science Learning Centre in York is offering a fantastic opportunity to improve your science communication skills with a two-day course on engagement with schools and young people on 18-19 October 2010.
EU directive on animal research becomes law
Yesterday the President of the European Parliament, and the Belgian State Secretary (representing the EU countries) put pen to paper and signed the new EU Directive 8869/10 in the use of animals in scientific research.
Retinal cells transplanted into blind mice
Retinal cells, necessary for colour vision, have been successfully transplanted into blind mice.
Loss of gene makes mice smarter
Mice with a disabled RGS14 gene are able to remember objects and learn to navigate mazes better than normal mice.
Tasmanian Devil genome sequenced
The Tasmanian Devil is at risk of extinction in the wild due to a transmissible cancer passed on when one animal bites another.
Drug reverses diabetes nerve damage
Diabetes can cause the death of nerves in the body's extremities, a condition known as diabetic peripheral neuropathy (DPN).
Single gene regulates motor neurons in the spinal cord
As a normal mammalian body grows, hundreds of motor neurons grow from the spinal cord to the muscles they will control.
Support for research that uses animals containing human material
The public broadly supports research on animals containing human material, according to an Ipsos Mori survey of 1,042 people.
European parliament votes on animal research directive
Today the European Parliament agreed on the final text of the new Directive concerning the use of animals in research.
Anti-clotting medicine attacks lupus
Lupus is a chronic disease where the body's own immune system attacks healthy tissue, causing inflammation, pain and damage in organs, particularly the kidneys.
How fish oils reduce inflammation
The omega-3 fatty acids DHA and EPA found in oily fish reduce inflammation, which in turn reduces the symptoms of arthritis and reduces the risk of heart attacks and strokes.
Rat pancreas grows in mouse
An ultimate goal of regenerative medicine is the generation of organs derived from a patient's stem cells.
Why older women fail to conceive
As women get older the chances of infertility, birth defects and developmental disabilities go up.
Malaria cured in mice
Increasing resistance to anti-malarials, such as those based on Artemisinin, have prompted a need for new treatments.
Resetting body clock in mice
Researchers have successfully used a chemical to reset and restart the natural 24-hour body clock in mice.
New approaches to animal research in schools
Animal research is a favourite topic when teachers are looking for a sure-fire way to get their students interested in the ethics of science, but are schools getting all they can from this complex, sometimes difficult, always fascinating subject?
Monkeys survive lethal Ebola and Marbug
Monkeys treated with a therapy that targets specific viral genes survived deadly Ebola and Marbug infections, a new study reports.
Magnetic medicines treat brain tumours
The barrier between blood vessels and the brain may no longer limit the delivery of medicines to tumours, research on rats shows.
Shellfish toxin testing
The recently published Annual report (2009) of the Animals Scientific Procedures Inspectorate and Division highlights progress towards suitable alternatives to replace the use of mice in the testing for toxins in shellfish.
UGUST 20, 1960: MOSCOW The Soviet Union today launched its second cosmic space ship, the Soviet news agency, Tass, said. The space ship carries animals, including two dogs.
GM rats promise better disease models
Scientists have created a ‘knockout rat' that can be used to model certain diseases in the same way as mice.
Chillis may reduce blood pressure
Capsaicin, a compound found in chilli peppers, has been found to reduce high blood pressure in rats.
Mouse clues to testicular cancer
For the first time scientists will be able to study the development of human testes in mice.
'Home grown' joints
The body's own cells could be used to aid the repair of joints, a pioneering rabbit study has revealed.
Puma may aid tumour growth
A study on mice suggests that cell suicide may encourage tumours to grow instead of destroying them.
Mouse research has revealed a link between bone remodelling, blood sugar and diabetes.
7,000 and counting...
Are you a school science teacher or a GCSE science student? Don't miss out next year - invite a volunteer speaker into your schoo
Ferrets, flu, fish and pharmaceuticals
Grants worth £4 million have just been announced for 13 science projects that aim to minimise the use of laboratory animals and improve their welfare.
Down syndrome: two genes crucial
Some of the symptoms relating to Down syndrome have been linked to two genes on chromosome 21, a study on mice has shown.
Protein linked to heart failure
Elevated levels of the protein CIB1 causes enlargement of the heart and subsequent heart failure, according to rodent research.
Primitive cells help blind mice see
Primitive retinal cells, that were previously thought to have no role in image formation, can help blind mice see.
Scientists watch armed immune cells fight cancer
Armed and tagged immune cells can be watched attacking tumours in mice in real time.
A light on Parkinson's
Shining a laser into the brain may ease the symptoms of Parkinson’s, a new study in mice has shown.
A pill that could reverse Alzheimer’s
A new compound that may reverse Alzheimer’s in humans has proven successful in rats and mice.
Physical, social stimulation may starve tumours
Mice with cancer living in enriched environments had smaller tumours, new research has revealed.
Artificial lung an alternative test-bed?
A functional artificial lung on a chip, which mimics the behavour of mouse lungs, has been created.
Cancers linked by faulty gene
Prostate cancer and hereditary breast cancer could be linked by the same gene, research on mice suggests.
New guidelines for reporting research
The National Centre for the Reduction, Refinement, and Replacement of animals in research (NC3Rs) has published a list of guidelines for scientists to follow when reporting the results of research involving animals.
UK Bioscience Sector outlines principles for implementing new Directive
The UK Bioscience Sector has produced a set of principles for the implementation and transposition of the revised EU Directive concerning the use of animals in research.
European public opinion divided
The European Commission has published a survey on the public's opinion of science and technology.
Rats breathe using lab lungs
For the first time rats have been able to breathe using lab grown lungs, a new study reports.
What R you watching? An interactive resource for schools
What R you watching? our latest online interactive educational resource, is now live on the UAR site.
A guide for UK institutions on the new EU Directive
The revised European Directive on animal research (EU8869/10) should be formally 'adopted' in Europe during summer 2010.
Weakened virus makes better vaccine
Rewriting the genetic code of the flu virus has helped to produce a stronger immune response, studies on mice have shown.
Gut bacteria may trigger arthritis
A novel study has uncovered a link between stomach bacteria and the development of rheumatoid arthritis in mice.
Painkiller from sea snail venom
A new painkiller is 100 times more potent than other painkillers, tests on rats have revealed.
Liver grafts grown in the lab
Scientists are a step closer to producing artificial livers after successfully producing a rat liver graft from stem cells.
Plastic antibodies attack bee stings
Immune system molecules made from plastic have functioned successfully in the first tests involving mice.
UK government minister to discuss animal research policy
The Home Office minister with responsibility for animal research, Lynne Featherstone, has agreed to meet the bioscience sector to discuss policy issues.
Canine cancer consortium
Two organisations have joined together to further research into canine cancer.
Extra chromosome protects against cancer
An extra copy of chromosome 21 may boost protection against cancer, research on mice suggests.
Scar tissue process revealed
Research on mice has revealed the process which limits the accumulation of excessive scar tissue.
The ultimate mouse gene study
A global effort announced recently could lead to the ultimate mouse model of human disease. The International Mouse Phenotyping Consortium (IMPC) aims to explain and share the functions of genes in mice.
The Marks & Spencer bunnies
Some may have seen the full page advert by the retailer Marks & Spencer (M&S), with pictures of rabbits, proclaiming its commitment not to test cosmetics or household products on animals.
The Animal Protection Party and the UK General Election
Just over a month has passed since the 2010 General Elections and the resulting Coalition government is beginning to outline their new policies.
Tremors caused by spinal malfunction
The mechanism which causes severe tremors in people with Parkinson's disease could be controlled through the spine, research on monkeys suggests.
RSPCA and LASA produce new guidelines
Ethical Review Process (ERP) bodies within animal research institutions now have the tools to "develop more efficient and effective processes".
Mystery of lithium action solved
The mechanism by which lithium works to reduce inflammation in the brain has been discovered in a study on rats.
New grants for science teachers
No understanding of how science works is complete without some knowledge of the way we use research animals.
Stem cell hope for deafness
Growing hair cells from stem cells could offer personalised treatments for deafness in the future, scientists studying mice suggest.
Dogs knees hold sporting injury clue
Canine genetics may be able to explain why both humans and dogs develop ligament injuries.
New treatment targets source of asthma
Lowering the production of specific immune cells could prevent asthma attacks, research on mice shows.
Council agrees stricter rules for animal experimentation
The European Council of Ministers has announced agreement on the draft Directive for the Protection of Animals used for Scientific Purposes.
Pigs are a new ideal model for cystic fibrosis
The cause of cystic fibrosis (CF) is becoming clearer after scientists used pigs as models instead of mice.
First trials for stem cell transplant into human spine
Stem cells have been injected into the human spine in a pioneering trial to test the safety of the technique, with the hope of treating a debilitating neurodegenerative condition.
Broccoli chemical kills cancer cells
A chemical in broccoli can kill breast cancer cells and halt tumour growth, accroding to new research on mice.
Hormone injection fights bone death
Bone death, a side effect of steroid medication, could be prevented according to new studies using rabbits.
Chilli-like chemical part of the pain pathway
A group of substances similar to those that give chillies their kick are part of the body's pain mechanism, research on mice has shown.
Study points to new cell culprit for epilepsy
In the past, research on epilepsy has focused on nerve cells, or neurons.
Artificial skin graft success
Artificial human skin developed in the laboratory has been successfully grafted onto mice.
Parties outline their stances on animal research
As the election manifestos from the political parties have been published, we have been having a look to see what they have to say about animal research.
Tribunal rules in favour of UK University in FOI case
A Freedom of Information (FOI) request made nearly three years ago has reached its conclusion, at least for now, with a ruling by the Information Tribunal.
Antifungal drug reduces tumour size
A medicine currently used to treat fungal infections successfully slows tumour growth in mice, according to new research.
Duck gene helps fight flu in chickens
Influenza protection can be transferred across species, say scientists who have identified a key gene in ducks.
Fat-free proteins kill tropical disease bug
Parasites which cause sleeping sickness can be killed by altering the proteins that they are dependent on, studies on mice show.
Agreement on European regulation
The European Parliament and Council representatives have reached an agreement on the final details of the revisions made to Directive 86/609/EEC on animal experimentation.
Enzymes are target for lung cancer treatment
‘Switching off' certain enzymes helps reduce tumours in mice, research has shown.
Synthetic ‘organ' helps stop gout
A plastic capsule implanted under the skin could help regulate metabolic processes, a study on mice has revealed.
RSPCA and GCSE science
The RSPCA's latest foray into schools education is a smart new web resource for GCSE science with a substantial chunk dedicated to exploring the ethics of animal research.
3Rs in front of the camera
If there is one thing that anti-vivisection campaigns are good at, it's providing vivid imagery.