What rodents have taught us about spatial cognition and memory
On Monday Dec 3 the 82nd Paget Lecture will be given by Nobel laureate Professor John O’Keefe, Professor of Cognitive Neuroscience, jointly at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and in the Department of Cell & Developmental Biology, Division of Biosciences at UCL.
In 2014 John won the Nobel Prize in Physiology or Medicine for the discovery of cells that constitute a positioning system in the brain - an ‘inner GPS’ - that enables us to orient ourselves.
The lecture will be live streamed to our facebook page and shortly afterwards a video of the lecture will be available here.
Professor O'Keefe, who won the award jointly with Professors May-Britt Moser and Edvard Moser of the Norwegian University of Science and Technology, discovered the first component of this positioning system in 1971 when he found a type of nerve cell in the hippocampus that became activated whenever a rat was in one location in a room, with a different set of cells active when the rat was in a different area. He concluded that these 'place cells' formed a map of the room. In 2005, the Mosers identified a nerve cell that allows for precise positioning and pathfinding. The place cells and nerve cells discovered make it possible for the brain to determine position.
The Nobel Assembly said today: "The discoveries of John O'Keefe, May-Britt Moser and Edvard Moser have solved a problem that has occupied philosophers and scientists for centuries - how does the brain create a map of the space surrounding us and how can we navigate our way through a complex environment?
"The discovery of the brain's positioning system represents a paradigm shift in our understanding of how ensembles of specialised cells work together to execute higher cognitive functions. It has opened new avenues for understanding other cognitive processes, such as memory, thinking and planning."
82nd Paget Lecture, 2018, Professor John O'Keefe, 2014 Nobel Prize, brain cells, positioning system, inner GPS