Paget Lecture 2019 Nancy Rothwell

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The Stephen Paget Memorial Lecture celebrates the life of Stephen Paget. He was the founder of the Research Defence Society in 1907 which later became Understanding Animal Research. Professor Dame Nancy Rothwell presented the 83rd Paget Lecture, with her talk ‘a stroke of bad luck’.

Nancy is President and Vice-Chancellor of the University of Manchester. Alongside her many past and present professional appointments, Nancy was also Chair of the Research Defence Society from 2004 to 2007.

During her lecture, Nancy spoke about how her early work focused on weight loss and metabolism in disease but when she discovered that blocking cytokine could reduce, not only metabolism and weight loss, but also brain damage in an animal model of stroke, she switched field to concentrate on stroke research. Her current research focuses on the role of inflammation in brain disease and she has identified the role of the cytokine interleukin-1 in diverse forms of brain injury. Her recent studies have begun to elucidate the mechanisms regulating interleukin-1 release and its action, and her group is conducting clinical trials of an interleukin-1 inhibitor in stroke. Someone has a stroke every 5 minutes in the UK so we hope that one day these patients might benefit from Nancy’s work.

Transcripts for previous Paget Lectures going back to 1927, and videos going back a little less far, can be found here.